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Learn about Xylometazoline uses, dosage, side effects, food interactions, and more. Get all the details about Xylometazoline from MedicinesFAQ. Xylometazoline is a selective alpha-1 adrenergic agonist belonging to Nasal Decongestants. Xylometazoline is used in treating Nasal congestion. Xylometazoline is rapidly absorbed after intranasal or oral administration. When administered intranasally, xylometazoline is mainly absorbed ... Find patient medical information for xylometazoline nasal on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Xylometazoline is a direct-acting alpha-adrenergic agonist used for the symptomatic treatment of nasal congestion and minor inflammation due to allergies or colds.