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USMLE United States Medical Licensing Exam USMLE is governed by a committee that includes members from the ECFMG, FSMB, NBME, and the public. Before you can apply for a medical license, you must pass a three-step test called the United Read More ... The United States Medical Licensing Examination ( USMLE ) is a three-step examination program for medical licensure in the United States. The first two exams are held during the college period. The United States Medical Licensing Examination ( USMLE ) is required to gain a license to practice medicine within the US. It assesses the essential skills for safe and effective patient care and provides a common standard of assessment for medical licensure. This USMLE complete guide will provide all the information you need for applying and undertaking the USMLE , including eligibility, registration and fees, and the different USMLE steps and materials to prepare. To apply for USMLE examinations, you must submit an application through the appropriate registration entity as described below. Note: Step 1, Step 2 CK, and Step 3 are not offered on major local holidays.