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Skin is the largest organ in the body, protecting it from external elements. Skin consists of many layers, made of water, protein, fats and minerals. Layers of the Skin Although you may not typically think of the skin as an organ, it is in fact made of tissues that work together as a single structure to perform unique and critical functions. The skin and its accessory structures make up the integumentary system, which provides the body with overall protection. The skin is made of multiple layers of cells and tissues, which are held to underlying structures by connective tissue (Figure 1). The deeper layer of skin is well vascularized (has ... Human skin, in human anatomy, the covering, or integument, of the body’s surface that both provides protection and receives sensory stimuli from the external environment. The skin consists of three layers of tissue: the epidermis, an outermost layer that contains the primary protective structure, The skin is the largest organ in the body, covering its entire external surface. The skin has 3 layers—the epidermis, dermis, and hypodermis, which have different anatomical structures and functions (see Image. Cross Section, Layers of the Skin).