Stiff person syndrome is a rare, progressive movement disorder that affects your central nervous system. It causes muscle stiffness and painful muscle spasms. Stiff person syndrome (SPS) is a rare disorder that causes disabling muscle stiffness and spasms. It is an autoimmune neurological disorder that occurs when the body’s immune system attacks certain enzymes involved in muscle relaxation. Stiff Person Syndrome (SPS) is a rare and complex autoimmune neurological disorder characterized by progressive muscle stiffness, rigidity, and painful spasms. Stiff person syndrome (SPS) is a rare autoimmune disorder that affects the brain and spinal cord, causing muscle rigidity and spasms. Learn about the diagnosis, treatment, and complications of SPS, and how it differs from other conditions.

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