SOOTHE definition: 1. to make someone feel calm or less worried: 2. to make a part of the body less painful: 3. to…. Learn more. Soothe definition: to tranquilize or calm (a person or their emotions); relieve, comfort, or refresh.. See examples of SOOTHE used in a sentence. 'Soothing' conveys a sense of relief and tranquility, making it a word commonly used to describe actions, sounds, or environments that promote a sense of relaxation and well-being. Having a calming, assuaging, or relieving effect.... Click for English pronunciations, examples sentences, video.