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SENESCENCE definition: 1. the fact of becoming older, and therefore being in less good condition and less able to function…. Learn more. Cell senescence — a state of irreversible cell-growth arrest — has important physiological functions and is a key driver of ageing. Senescence articles from across Nature Portfolio Senescence is the process by which cells irreversibly stop dividing and enter a state of permanent growth arrest without undergoing cell death ... Senescence is the process by which cells stop dividing and enter a state of permanent growth arrest without undergoing cell death. Senescence cells get old and weaken, causing a decline in tissue function and decay. Senescence in plants is a programmed death of leaves as part of developmental cycles. In animals, senescent cells contribute to aging and age-related diseases. Senescence can be induced by unrepaired DNA damage or other cellular stresses. It plays a role in normal development ...