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Prophase is the first step of mitosis. During this stage, chromatin condenses into chromosomes, the nucleus disappears, and spindle fibers form. Prophase I This is a long and complex phase and differs greatly from mitotic prophase. Prophase is divided in five phases. In the leptotene stage the chromosomes divide longitudinally to form pairs of sister chromatids. Self-duplication of genetic material has already taken place. In the zygotene stage pairing of homologous chromosomes (synapsis) takes place, a requirement for intrachromosomal recombination process. In the pachytene phase pairing is complete, chromosomes begin to spiralize ... Next, the nucleus dissolves. At the end of prophase, the spindle apparatus moves the replicated chromosomes to the center of the cell. Figure 1. The cell cycle depicts the stages in the life of a cell. Those phases are interphase (with the G1, S phase, and G2 phase) and mitosis (prophase, metaphase, anaphase, telophase). Prophase is the first step of cell division in mitosis. Prophase is the initial stage of cell division in eukaryotes, characterized by the condensation of chromosomes, the separation of centrioles, and the breakdown of the nuclear envelope. What Happens in Prophase?
