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Potassium Clavulanate is a beta-lactamase inhibitor that enhances the activity of antibiotics against bacteria. It is used to treat infections of the lungs, skin, ears, sinuses, and urinary tract. Learn more about its dosage, contraindications, and interactions on Lybrate. Clavulanic acid is a β-lactam drug that enhances the activity of penicillin-group antibiotics against bacteria that produce β-lactamase. It is combined with amoxicillin or ticarcillin in various preparations and has some off-target effects in the nervous system. Name Clavulanate potassium Drug Entry Clavulanic acid Clavulanic acid is a beta-lactamase inhibitor that is frequently combined with Amoxicillin or Ticarcillin to fight antibiotic resistance by preventing their degradation by beta-lactamase enzymes, broadening their spectrum of susceptible bacterial infections. 8 Clavulanic acid is derived from the organism Streptomyces clavuligerus. 1 When it is combined with amoxicillin, clavulanic acid is frequently known as Augmentin, Co-Amoxiclav, or ... Clavulanate Potassium is a semi-synthetic beta-lactamase inhibitor isolated from streptomyces. Clavunalate potassium contains a beta-lactam ring and binds strongly to beta-lactamase at or near its active site. This protects other beta-lactam antibiotics from beta-lactamase catalysis.