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Polymyxin B is an antibiotic used to treat bacterial infections. It can cause kidney and nerve problems, and interact with other drugs. Learn about its dosage, side effects, and precautions. Polymyxin B is an effective antibiotic medicine to treat infections of the urinary tract, eye, ear, skin, bloodstream, and layers covering the brain (meninges) caused by sensitive gram-negative bacteria. Polymyxin B is an antibiotic derived from a bacterium that treats infections caused by Gram negative bacteria. It can be given by injection, inhalation, or topically, and has various side effects and interactions. Polymyx- B Injection is an antibiotic that fights bacteria and treats severe infections. It is given by injection or drip and may cause side effects like anaphylaxis, kidney damage, or neurotoxicity.