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Penile cancer symptoms vary person to person. 1. Change in skin of the penis 2. Wart-like growth or lesion 3. Open sore 4. Reddish rash 5. Small, crusty bumps. Penile cancer usually forms on or under the foreskin. Human papillomavirus (HPV) causes about one-third of penile cancer cases. When found early, penile cancer is usually curable. Start here to find information on penile cancer treatment and research. Cancer of the penis affects the skin and tissues of the penis . Learn the symptoms to watch for and about risk factors, diagnosis, and treatment. Penile Cancer : Symptoms and Treatments Penile cancer , though relatively rare, is a serious condition that requires early detection and prompt treatment. This malignancy originates in the tissues of the penis and can manifest in several forms, each varying in severity and treatment options.