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Ondansetron injection is used to prevent and treat nausea and vomiting caused by surgery, chemotherapy, or radiation. Learn its uses, dosage, and safety tips. 2.3 Administration Instructions for ZOFRAN ODT Orally Disintegrating Tablets Do not attempt to push ZOFRAN ODT tablets through the foil backing. With dry hands, PEEL BACK the foil backing of 1 blister and GENTLY remove the tablet. IMMEDIATELY place the ZOFRAN ODT tablet on top of the tongue where it will dissolve in seconds, then swallow with saliva. Administration with liquid is not necessary. Ondansetron is commonly available in tablet form and oral disintegrating tablets, providing convenient options for patients. The oral forms are typically administered before undergoing chemotherapy or radiation therapy, serving as a preemptive measure to mitigate the onset of nausea and vomiting associated with these treatments. Ondansetron is used to prevent nausea and vomiting that is caused by cancer medicines (chemotherapy) or radiation therapy. It is also used to prevent nausea and vomiting that may occur after surgery. Ondansetron works in the stomach to block the signals to the brain that cause nausea and vomiting.