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Myalgia is muscle aches and pain caused by various factors, such as injuries, overuse, drugs and illnesses. Learn about the symptoms, diagnosis and treatment of myalgia from Johns Hopkins Medicine. Myalgia, or muscle pain, can result from exercise, stress, infections, or chronic conditions like fibromyalgia. This article explains common causes, symptoms, and effective treatments including medication, topical creams, and natural remedies. Learn how to prevent and manage myalgia for better... Myalgia or muscle pain is a painful sensation evolving from muscle tissue. It is a symptom of many diseases. The most common cause of acute myalgia is the overuse of a muscle or group of muscles; another likely cause is viral infection, especially when there has been no injury. Long-lasting myalgia can be caused by metabolic myopathy, some nutritional deficiencies, ME/CFS, fibromyalgia, and amplified musculoskeletal pain syndrome. Myalgia is the medical term for muscle pain, which can have many causes, from overuse to disease. Learn how to identify, treat and prevent myalgia with Cleveland Clinic experts.