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Loneliness is a prevalent and global problem for adult populations, and a number of different studies have linked it to multiple chronic conditions, including: heart disease, lung disease, cardiovascular disease, hypertension, atherosclerosis, ... What does loneliness really mean? Here's all you need to know, from what causes it to how it might impact your health, plus ways to cope and prevent it. LONELINESS definition: 1. the state of being lonely 2. the state of being lonely. Learn more.