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Insulin resistance occurs when the body's cells become less responsive to the hormone insulin, which is produced by the pancreas. Insulin plays a vital role in regulating blood sugar levels by facilitating the uptake of glucose into cells for energy. Insulin resistance is a state in which a given concentration of insulin produces a less-than-expected biologic effect. Insulin resistance has also been arbitrarily defined as the requirement of 200 or more units of insulin per day to attain glycemic control and to prevent ketosis. The syndromes of insulin resistance actually make up a broad clinical spectrum, which includes obesity, glucose intolerance, diabetes, and the metabolic syndrome, as well as an extreme insulin-resistant state. [1 ... What is insulin resistance? Insulin resistance happens when cells in your muscles, fat and liver don’t respond to insulin as they should. This is also known as impaired insulin sensitivity. Insulin is essential for life and regulating blood glucose (sugar) levels. It means your pancreas must generate higher levels of insulin for insulin to have its proper effects. With insulin resistance, the pancreas produces more and more insulin. When the pancreas can no longer produce sufficient insulin for the body's demands, then blood sugar rises.
