Iga nephropathy: Immunoglobulin A (IgA) nephropathy

Immunoglobulin A (IgA) nephropathy, or IgAN, also known as Berger disease, is one of the leading causes of glomerulonephritis and renal failure. This disease is a prevalent form of glomerulonephritis characterized by the deposition of IgA in the glomerular basement membrane. Overview of IgA nephropathy, also known as Berger’s disease, an autoimmune disease that can damage your kidneys. Immunoglobulin A (IgA) nephropathy is deposition of IgA immune complexes in glomeruli, manifesting as slowly progressive hematuria, proteinuria, and, often, chronic kidney disease. Diagnosis is based on urinalysis and renal biopsy. Treatment options include angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs), corticosteroids and sometimes other immunosuppressants. Prognosis is generally good. IgA nephropathy is a kidney disease caused by abnormal antibodies that damage the glomeruli. Learn about the symptoms, diagnosis, treatment and outlook of this condition from Cleveland Clinic experts.