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Learn the 25 potential side effects of ibuprofen here, as well as how it affects COVID-19. Ibuprofen Ibuprofen is a pain reliever, belonging to the non-steroidal anti-inflammatory class of drugs. It is pretty much a popular medicine and helps in the treatment of inflammation, pain, fever (by lowering the body temperature), etc. It usually blocks the production of prostaglandins, which are the ones that promote pain, fever, and inflammation. Medicine has much more to it. Let us start by discussing its uses in detail. Learn about the side effects of ibuprofen, from common to rare, for consumers and healthcare professionals. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) and a common treatment for relieving fever, pain, and inflammation. As with any medication, ibuprofen can cause side effects.