Ibuprofen oral suspension bp: In vivo studies indicate that ibuprofen

In vivo studies indicate that ibuprofen is well absorbed orally from the suspension formulation, with peak plasma levels usually occurring within 1 to 2 hours (see Table 1). For pain, fever and symptoms of cold and influenza: The daily dosage of Ibuprofen oral suspension is 20-30 mg/kg body weight in divided doses. Using the oral dosing syringe provided this can be achieved as follows: A: Transfer a volume of Oral Suspension, equivalent to about 200 mg of ibuprofen, to a separator containing about 10 mL of chloroform, and shake for about 1 minute. Allow the layers to separate, and pass the lower chloroform layer through a filter containing about 2 g of anhydrous sodium sulfate. Use the filtrate as the test solution. [note Retain a portion of this test solution for use in Identification test B.] Separately apply 10-µL portions of the test solution and of a Standard ... DESCRIPTION The active ingredient in Ibuprofen Oral Suspension, USP is ibuprofen, which is a member of the propionic acid group of nonsteroidal anti-inflammatory drugs (NSAIDs). Ibuprofen is a racemic mixture of [+]S- and [-]R-enantiomers. It is a white to off-white crystalline powder, with a melting point of 74° to 77°C. It is practically insoluble in water (<0.1 mg/mL), but readily soluble in organic solvents such as ethanol and acetone. Ibuprofen has a pKa of 4.43 ± 0.03 and an n ...