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Hypocalcemia is a common biochemical abnormality that can range in severity from being asymptomatic in mild cases to presenting as an acute life-threatening crisis. 1 Serum calcium levels are regulated within a narrow range (2.1 to 2.6 mmol/L) by 3 main calcium-regulating hormones—parathyroid hormone (PTH), vitamin D, and calcitonin—through their specific effects on the bowel, kidneys, and skeleton. 1, 2 Approximately half of the total serum calcium is bound to protein, and the remaining ... Hypocalcemia is a condition of low calcium levels in the blood, which can affect bones, muscles, nerves, and heart. Learn about the causes, symptoms, diagnosis, treatment, and prevention of calcium deficiency disease. Hypocalcemia is a condition of low calcium levels in the blood serum, which can cause numbness, muscle spasms, seizures, or cardiac arrest. Learn about the common causes, such as hypoparathyroidism, vitamin D deficiency, or medications, and how to diagnose and treat hypocalcemia . Hypocalcemia is not seen as frequently as hypercalcemia is, but it can be potentially life-threatening if not appropriately recognized and promptly treated. Most hypocalcemia causes are acquired, but some are inherited. Clinical presentations can vary from asymptomatic to life-threatening arrhythmias or seizures.