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Mechanism of Friedel-Crafts Alkylation Reaction of a Benzene The mechanism of the Friedel-Crafts Alkylation Reaction of benzene is discussed in the steps mentioned below: Step 1: The formation of an electrophilic carbocation is the first step. In this step, alkyl halide reacts with the Lewis acid such as anhydrous aluminium chloride or ferric chloride which results in the generation of electrophilic carbocation. Learn how to prepare alkylbenzenes and ketones by electrophilic aromatic substitution reactions involving carbocations. Understand the mechanisms, limitations and applications of Friedel-Crafts alkylation and acylation reactions. Friedel-Crafts Alkylation This Lewis acid-catalyzed electrophilic aromatic substitution allows the synthesis of alkylated products via the reaction of arenes with alkyl halides or alkenes. Since alkyl substituents activate the arene substrate, polyalkylation may occur. A valuable, two-step alternative is Friedel-Crafts Acylation followed by a carbonyl reduction. Friedel–Crafts alkylation is an electrophilic aromatic substitution reaction where an alkyl group is introduced to an aromatic ring using an alkyl halide and a Lewis acid catalyst.
