Down syndrome is caused by an extra chromosome 21, affecting physical and intellectual development. Common physical traits of Down syndrome include a round face, upturned eyes, and a short build. Down syndrome increases the risk of developing complications and other health conditions. Down syndrome is a genetic condition that impacts the brain and body’s development. Learn about the causes, symptoms , and diagnosis of this condition. Learn about the physical, cognitive, and behavioral symptoms of Down syndrome in infants, children, and adults. Find out how doctors test for Down syndrome during pregnancy and after birth. The symptoms of Down syndrome vary from person to person, and people with Down syndrome may have different problems at different times of their lives.