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Diagnosis is the process of identifying or determining the nature and cause of a disease or injury through evaluation of patient history, examination, and review of laboratory data. The web page provides various definitions of diagnosis from different medical sources, as well as related terms and patient discussions. Diagnosis definition: the process of determining by examination the nature and circumstances of a diseased condition.. See examples of DIAGNOSIS used in a sentence. The meaning of DIAGNOSIS is the art or act of identifying a disease from its signs and symptoms. How to use diagnosis in a sentence. n. the process of determining the nature of a disorder by considering the patient’s signs and symptoms, medical background, and – when necessary – results of laboratory tests and X-ray examinations. Unlike therapeutic procedures, diagnostic processes usually do not directly benefit the patient in terms of treatment. See also differential diagnosis, prenatal diagnosis. Compare prognosis. —diagnostic adj.