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Antagonist can mean a person who opposes or disagrees with another, a muscle that performs the opposite action, or a substance that stops a reaction. Learn more about the different meanings and usage of antagonist with examples and translations. Antagonist definition: a person who is opposed to , struggles against, or competes with another; opponent; adversary.. See examples of ANTAGONIST used in a sentence. An antagonist is a character that opposes, competes with, or conflicts with the main character, known as the protagonist, in a story or narrative. An antagonist is a person, muscle, drug, or substance that opposes or competes with another. Learn the meaning , synonyms, and usage of antagonist in different contexts, such as drama, pharmacology, and dentistry.