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Analgesic combination products contain at least one analgesic in combination with another medicine or medicines. An analgesic is the name given to a medicine that relieves pain without putting you to sleep or making you lose consciousness. Analgesics may also be known as painkillers or pain relievers. Clinical Use of Analgesic Drugs The choice and route of administration of analgesic drugs depends on the nature and duration of the pain. A progressive approach is often used, starting with nonsteroidal anti‐inflammatory drugs, supplemented first by weak opioid analgesics, and then by strong opioids. Key takeaways Analgesics are pain-relieving medications available in both over-the-counter and prescription forms. NSAIDs, opioids, and combination drugs treat different types of pain, from mild headaches to severe injuries. Some non-analgesic drugs, like antidepressants or anticonvulsants, can also relieve nerve-related pain. Side effects and risks vary by type and may include liver damage, kidney problems, or an increased risk of dependence. analgesic, any drug that relieves pain selectively without blocking the conduction of nerve impulses, markedly altering sensory perception, or affecting consciousness. This selectivity is an important distinction between an analgesic and an anesthetic.