The urea cycle is a type of metabolism in the liver that that changes toxic ammonia into less toxic urea for healthy removal, which is necessary for the body’s nitrogen balance. The urea cycle is the body’s way of converting toxic ammonia into urea. Ammonia originates from protein catabolism whether that is secondary to a high-protein diet, deaminations, or during the period of prolonged starvation. Urea is formed, enters the bloodstream, is filtered by the kidneys, and is eventually excreted in the urine. The biochemical part of excretion is urea synthesis using the urea cycle , also known as the Ornithine Cycle. It is also known as the Kreb-Henseleit cycle and occurs in the liver. The conversion of ammonia into urea through a series of biochemical reactions is known as the urea cycle or ornithine cycle. It takes place in the liver with the help of mitochondrial and cytosolic enzymes.
