What Is Testicular Cancer ? Cancer that starts in the testicles is called testicular cancer . Cancer starts when normal cells begin to grow out of control. To understand testicular cancer , it helps to know about the normal structure and function of the testicles. Testicular cancer most often begins in germ cells (cells that make sperm). It is rare and is most frequently diagnosed in men ages 20 to 34. Most testicular cancers can be cured, even if diagnosed at an advanced stage. Start here to find information on testicular cancer treatment, screening, and statistics. Learn about testicular cancer , the most common cancer among men aged 15 to 35. Find out how to recognize the signs, what causes it, how it's diagnosed and treated, and how to prevent it.