Learn about sulfasalazine as a treatment for RA patients. Read more about what to expect, side effects & dosing information when considering sulfasalazine . Generic Name Sulfasalazine DrugBank Accession Number DB00795 Background Sulfasalazine is an anti-inflammatory drug structurally related to salicylates and other non-steroidal anti-inflammatory drugs. It is indicated for managing inflammatory diseases such as ulcerative colitis and rheumatoid arthritis (RA). 16, 10 Metabolized by intestinal bacteria, sulfasalazine is broken down into mesalazine and sulfapyridine, 2 compounds that carry out the main pharmacological activity of sulfasalazine ... Sulfasalazine is a medication used to treat ulcerative colitis, rheumatoid arthritis, and Crohn's disease. It can cause various side effects, interact with other drugs, and have serious warnings and precautions. Learn more about sulfasalazine dosage, administration, and brand names. Pharmacodynamics The mode of action of sulfasalazine (SSZ) or its metabolites, 5-aminosalicylic acid (5-ASA) and sulfapyridine (SP), may be related to the anti-inflammatory and/or immunomodulatory properties that have been observed in animal and in vitro models, to its affinity for connective tissue, and/or to the relatively high concentration it reaches in serous fluids, the liver and intestinal walls, as demonstrated in autoradiographic studies in animals. In ulcerative colitis, clinical ...
