Learn the main differences and similarities between eukaryotic and prokaryotic cells, the two main types of organisms on Earth. See a comparison chart, definitions, examples, and diagrams of their structures and features. Prokaryotic and eukaryotic cells are the two primary types of cells. Prokaryotic cells lack a defined nucleus and membrane-bound organelles, while eukaryotic cells have a true nucleus and membrane-bound organelles. Prokaryotic Cell and Eukaryotic Cell: Prokaryotic Cells and Eukaryotic Cells are two types of cells. The major difference between these two is that Prokaryotic Cells do not have any membrane-bound organelles. Eukaryotic cells contain a nucleus with a nuclear membrane enclosing multiple chromosomes, while prokaryotic cells have a single chromosome.