Neosporin is a combination of antibiotics that prevent infections in minor cuts, scrapes, or burns on your skin. Learn how to use it, what side effects to watch out for, and what interactions to avoid with other drugs. Overview: Topical triple antibiotic is applied to your skin to reduce the risk of infection from minor wounds or injuries. Topical triple antibiotic should only be used on your skin after... Neosporin Antibiotic Ointment is a good over-the-counter antibiotic for minor skin wounds, as it combines three effective antibiotics (Bacitracin, Neomycin, and Polymyxin B) to help prevent or treat bacterial infections. Learn how to use Neosporin properly, what it can be used for, what ingredients it contains, and more. Discover Neosporin® Original Triple Antibiotic Ointment . Made with polymyxin, bacitracin, and neomycin, this first aid ointment helps protect minor wounds from infection.