The Mentzer Index is particularly useful in distinguishing between iron deficiency anemia, which typically shows a higher index (>13), and beta-thalassemia trait, which usually presents a lower index (≤13). It is a non-invasive, cost-effective, and readily available tool in many clinical settings. Common FAQs What does a high Mentzer Index ... Mentzer index was found to be more reliable to detect true positive cases for β thalassemia trait with a sensitivity of 93.75%, specificity of 92.73%. Conclusion: Iron deficiency anaemia and thalassemia with many overlapping features can be differentiated by few parameters blood indices like Mentzer index . Use this screening tool to assist in differentiating between iron deficiency anemia (IDA) and beta thalassemia trait (BTT). Please fill out required fields. This score is non-diagnostic, and results should be confirmed with additional testing. The Mentzer index is a ratio of MCV and RBC count that helps distinguish iron deficiency anemia from beta thalassemia trait. Learn how it is calculated, interpreted and used in clinical practice.