Definition of manipulate verb in Oxford Advanced Learner's Dictionary. Meaning , pronunciation, picture, example sentences, grammar, usage notes, synonyms and more. Manipulate refers to It can involve using various tactics, such as deception, persuasion, or coercion, to influence the behavior or decision-making of others. Manipulation can be used in many different contexts, such as personal relationships, politics, business, and advertising. manipulate (third-person singular simple present manipulates, present participle manipulating , simple past and past participle manipulated) (transitive) To move, arrange or operate something using the hands (transitive) To influence, manage, direct, control or tamper with something The meaning of MANIPULATE is to treat or operate with or as if with the hands or by mechanical means especially in a skillful manner. How to use manipulate in a sentence.