insane meaning , definition , what is insane : completely stupid or crazy, often in a w...: Learn more. The adjective ' insane ' has its origins in the Latin word 'insanus,' which is a combination of 'in,' meaning 'not,' and 'sanus,' meaning 'sound' or 'healthy.' In its early use, ' insane ' directly referred to a lack of soundness or health, particularly in the context of one's mental state. It conveyed the idea of extreme mental instability, irrationality, or madness, indicating a departure from a sound and healthy state of mind. Over time, this term has continued to be associated with severe ... insane (comparative more insane or insaner, superlative most insane or insanest) Exhibiting unsoundness or disorder of mind; not sane; utterly mad. synonym quotations Synonyms: see Thesaurus: insane Learn the meaning and usage of the adjective insane , which can describe someone with severe mental illness, someone who is very annoyed or foolish, or something that is wild and uncontrolled. See examples, synonyms, and related terms.