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Buerger's disease or thromboangiitis obliterans is a condition that reduces blood supply to the hands and feet in smokers. Buerger's disease is a smoking-related vasculitis of small and medium-sized arteries, causing limb ischaemia and tissue loss. Learn about its symptoms, diagnosis, treatment, prevention and prognosis from BMJ Best Practice. Buerger’s Disease affects blood flow to the limbs, often caused by smoking. Learn about its symptoms, causes, diagnosis, and how to manage and prevent this serious vascular condition. Buerger’s disease is a rare illness that almost always affects smokers. It causes pain in your hands, feet, arms, and legs. Find out more about causes, symptoms, complications, diagnosis ...