Blue Baby Syndrome is a condition affecting infants, characterized by bluish skin due to oxygen deficiency. Learn about its symptoms, diagnosis, and treatment options. Blue baby syndrome , or cyanosis, is a bluish skin color caused by low oxygen in the blood. It can be due to heart, lung, or blood problems, and may require surgery or medication. Blue Baby Syndrome is a condition where an infant’s skin, lips, or nails appear bluish because the blood cannot carry enough oxygen. This can happen from birth (congenital) or develop later (acquired) in life. What is a blue baby syndrome ? Blue baby syndrome is a condition characterized by a change in skin colour in babies. The bluish tint is most evident in thin skin areas such as the lips, earlobes, and nail beds. It is due to heart, lung, or blood abnormalities. The baby takes on a bluish hue because of poorly oxygenated blood. Normally, blood is pumped from the heart to the lungs, where it receives oxygen. The blood is circulated back through the heart and then throughout the body.