Definition of affiliation noun in Oxford Advanced Learner's Dictionary. Meaning, pronunciation, picture, example sentences, grammar, usage notes, synonyms and more. Colleges shall give: Any Desk Id Screen Shot of the Issue Issue Description with the WhatsApp group AFFILIATION meaning: 1. a connection with a political party or religion, or with a larger organization: 2. a connection…. Learn more. An affiliation is an official connection to something. To have an affiliation to something is to be affiliated with it. The Tea Party pretty clearly has an affiliation with the Republican Party.